Sodium potassium pump pdf free

Mechanisms of sodium pump regulation american journal of. Structure, function and regulation of na,katpase in the kidney. Voiceover what i hope to do in this video is give ourselves an appreciation for the sodiumpotassium pump, and as the name implies, it pumps sodium and potassium, but it does it in different directions. Sodiumpotassium pump definition of sodiumpotassium. The idea of a pump in the cell membrane was introduced by r. To access free multiple choice questions on this topic, click here. Structure, function and regulation of na,katpase in the kidney core. Figure 1 illustrates how the na,kpump provides the driving force for widely different active. Several other examples are currently available in the pdb. Abstraci the nak exchange pump is represented as a net stoichiometrically coupled reaction, r.

The order of release of sodium and addition of potassium in the sodium potassium pump reaction mechanism. Atpase sodium potassium adenosine triphosphatase, also known as the na. Understanding the sodium pump and its relevance to disease. Karlish the na, kpump or nakatpase actively transports na and k ions across mammalian cell membranes to establish and maintain the characteristic trans. Regulation of this enzyme ion transporter and its individual isoforms is believed to play a key role in the etiology of some pathological processes. Pdf the cell membrane na,katpase is a member of the ptype family of. Pdf the sodiumpotassium pump is an information processing. The sodiumpotassium pump is an information processing element in brain computation article pdf available in frontiers in physiology 55. The na, katpase is a member of the ptype atpase family of cation pumps that use the free energy of hydrolysis of atp to.

Dean in 1941 in a paper entitled theories of electrolyte equilibrium in muscle 20. The sodiumpotassium pump is an information processing element in brain computation. Sodiumpotassium pump discusses an example of active transport in which membrane protein moves sodium and potassium ions against large concentration gradients. Internal potassium stimulates the sodiumpotassium pump by.

Discovery of the sodium potassium pump in the 1950s by a danish scientist, jens christian skou, marked an important step forward in our understanding of how ions enter and leave cells. The plasma membrane is a lipid bilayer that arranged asymmetrically, containing cholesterol, phospholipids, glycolipids. Ptype pumps the sodiumpotassium pump shown above and n the reverse from pdb entry 2zxe is one of a large class of ptype atpase pumps, so called because they all incorporate a phosphatelinked intermediate in their mechanism. Glucocorticoids have been shown to increase nak atpase activity in the rat kidney 4, 5 and more recently.

The sodiumpotassium pump weizmann institute of science. Karlish the na, k pump or nakatpase actively transports na and k ions across mammalian cell membranes to establish and maintain the characteristic trans. Kinetics of the inhibition of the nak pump by external sodium. Key words sodium, potassium, pump, atpase, na,katpase. The pump, which has adenosinetriphosphatase atpase. For every atp molecule that the pump uses, three sodium.